Treatment optimization of fluoropyrimidine-based chemotherapy
- Universiteit Universiteit Utrecht
- Promovendus Dr. Jonathan Knikman
- Promoters Prof. dr. J.H. Beijnen Prof. dr. H.J. Guchelaar
- Co-Promoters Dr. A. C ats
- Jaar 2024
"Fluoropyrimidines are among the most commonly used anticancer drugs used for multiple types of solid tumors. The studies described in this thesis are focused on improving the safety of fluoropyrimidine-based chemotherapy by individualized dosing based on dihydropyrimidine dehydrogenase activity (DPD) and pretreatment uracil concentrations".