Promotie onderzoek

To determine the need for repeated booster vaccinations in healthy individuals and to aid policymakers in future public health interventions for COVID-19. Gain insight into the immunogenicity of the additional bivalent booster vaccination in a representative sample of the healthy Dutch population. We aim to investigate three main topics: 
i) immunogenicity of bivalent vaccines after priming with adenovirus- or mRNA-based vaccines, 
ii) immunological recall responses and reactivity with relevant variants after booster vaccination, and 
iii) the necessity of booster vaccinations for the healthy population in the future.
 

All people living with HIV need life-long treatment with antiretroviral therapy (ART). However, ART coverage in children living with HIV continues to lag behind adults and many paediatric patients in sub-Saharan Africa still do not receive optimal paediatric treatment formulations or state-of-the-art drugs. Studies of efficacy and safety of these drugs in children have lagged behind, and the full range of appropriate formulations to treat younger children are yet to be developed for both first- and second-line treatments. 
 

Het optimaliseren van de antivirale behandeling van kinderen met HIV in Afrika door verdieping in de PK/PD van deze middelen, nieuwe formuleringen en het voorspellen van de PK middels modelleren. 
 

The aim of this project is to explore the 3D printing of peadiatric medicines. 3D printing technology enables the creation of medications with a wide range of dosages, shapes, flavors, and drug combinations, all customized to meet the unique needs of individual patients and specific disease conditions. Once the optimal formulations have been developed, the 3D printed medicines will undergo clinical trials for testing. 

The aim is to present current and new strategies university hospitals can undertake to contain costs of expensive drugs using a drug life cycle approach.