Promotie onderzoek

The research project entitled ‘Global psychotropic medication use and associated neurological outcomes’ aims to explore global patterns of psychotropic medication use with international big data from various countries.

The research project aims to perform a multinational pharmacoepidemiologic study in order to examine the mental health effects of the COVID-19 pandemic across vulnerable groups, including people with established psychiatric disorders including dementia and neurodevelopmental disorders.

The (positive) effects of antihypertensive drugs in the cardiovascular risk management are undoubted. However, like all drugs, antihypertensive drugs also have negative side-effects. Especially the elderly, are more susceptible for these adverse effects. It's not clear whether the benefits outweight the risks. So is it possible to deprescribe antihypertensive drugs and minimise risks for adverse events, while maintining blood-pressure levels in accordance with guidelines?  

• A prospective observational PK/PD to study the target attainment for β-lactam antibiotics in critical ill patients and its associated risk factors.
• A multi-centre, randomised controlled trial to assess the efficacy and cost-effectiveness of model-based TDM of beta-lactam and fluoroquinolone antibiotics.

1. Optimasation of the flucloxacillin absorptiontest.
2. PK modeeling of cefotaxim in critically ill patients.
3. PK modeling of flucloxacillin in mice.

Meerwaarde van clinical rules in de eerste lijn.

Optimalisatie van het clinical decision support system.