Het onderzoek is gericht op optimalisatie van de behandeling van colorectaal kanker middels farmacogenetica en farmacokinetische studies.
Identificeren van biomarkers, waaronder genetische variaties, die geassocieerd zijn met de effectiviteit en toxiciteit van platinumhoudende chemotherapie in de behandeling van patiënten met niet-kleincellig longcarcinoom.
The aim of this project is to provide insight in the use of biologicals, including biosimilars, in clinical practice and add to the safe and effective use of these agents. We also provide guidance on the implementation of biosimilars in clinical practice from the perspective of different stakeholders including prescribers, pharmacists and patients.
RHYME-RCT is a multi-center randomized controlled trial to identify and improve non-adherence in patients with resistant hypertension and are included from 10 peripheral and 2 academic hospitals. Non-adherence is measured by means of a validated dried blood spot method. This method includes 17 antihypertensive drugs from different drug classes.
New medicines are evaluated by registration authorities in order to assess their benefit-risk-balance. However, not every new medicine has to have an added therapeutic value compared to already available medicines. The real clinical relevance of new medicine is therefore sometimes unclear. In this research project, we want to investigate the views of healthcare professionals (HCPs) on clinical relevance of new medicines in primary care. We will discuss healthcare professionals’ views on clinical relevance of new COPD and T2DM medicines and also describe the reasons for prescribing new medicines, which is often not in line with guideline recommendations. Finally, we want to investigate how healthcare professionals assess the clinical relevance of medicines that obtained market access in the last years, and to investigate which pharmaceutical gaps (in other words: which diseases cannot be properly treated and would demand new therapies) HCPs identify in their daily practice.