Towards precision dosing in psychiatric patients.
- Universiteit Erasmus Medisch Centrum Rotterdam
- Promovendus Kajie Liang
- Promoters prof. dr. Birgit Koch
- Co-Promoters dr. Bram Dierckx
- Jaar 2022- 2026
Outpatient Parenteral Antimicrobial Therapy (OPAT) service provides antimicrobial therapy by parenteral infusion without hospitalization. Vancomycin is a widely used antibiotic in OPAT, however a drawback of its application in OPAT is the need for traditional blood sampling at a blood sampling facility for therapeutic drug monitoring. By developing a dried blood spot sampling method (i.e. a finger prick), enabling patients to collect their own sample at home, the costs of OPAT may be further reduced and patient satisfaction may be increased.
A prospective observational PK/PD to study the target attainment for β-lactam antibiotics in critically ill pediatric patients and associated risk factors.
Use population PK/PD modeling approach and consider evolving resistance development to better understand the development of drug resistance in anti-cancer treatments and to optimize and individualize anti-cancer treatment.
Drug repositioning is the application of existing drugs to new indications. We want to find out if it is possible to find new potentially effective drugs against individual tumors based on their unique gene expression patterns.