Bioanalysis and Biotransformation of Covalent Targeted Kinase Inhibitors in Oncology
- Universiteit Universiteit Utrecht
- Promovendus Irene Retmana
- Promoters Beijnen
- Co-Promoters Sparidans
- Jaar 2020 - 2024
The landscape of drug development as well as clinical practice has been changing over the last decennium, with the increasing availability and use of biobased therapies. This research is now focusing on the use and therapeutic drug monitoring of biobased factor VIII therapies in hemophilia A patients.
Part 1: Optimizing ribavirin therapy in transplant recipients with a chronic hepatitis E virus infection by devoloping a NONMEM model for ribavirin. Part 2: Improving immunosuppressive therapy in liver transplant recipients by performing 2 RCT's in which different immunosuppresive strategies will be compared to modify the tacrolimus related toxicity in this population. Part 3: Evaluate the contribution of an outpatient medication service for liver transplant recipients.
Outpatient Parenteral Antimicrobial Therapy (OPAT) service provides antimicrobial therapy by parenteral infusion without hospitalization. Vancomycin is a widely used antibiotic in OPAT, however a drawback of its application in OPAT is the need for traditional blood sampling at a blood sampling facility for therapeutic drug monitoring. By developing a dried blood spot sampling method (i.e. a finger prick), enabling patients to collect their own sample at home, the costs of OPAT may be further reduced and patient satisfaction may be increased.