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Farmacokinetiek en -dynamiek

Biobased factor VIII therapies in hemophilia A patients

  • Universiteit Universiteit Utrecht
  • Promovendus Anouk Donners
  • Promoters Toine Egberts
  • Co-Promoters Karin Rademaker Erik van Maarseveen
  • Jaar 2018 - 2022

The landscape of drug development as well as clinical practice has been changing  over the last decennium, with the increasing availability and use of biobased therapies. This research is now focusing on the use and therapeutic drug monitoring of biobased factor VIII therapies in hemophilia A patients.

Farmacokinetiek en -dynamiek

Therapeutic drug monitoring in neonatal saliva

  • Universiteit Amsterdam Universitair Medisch Centrum
  • Promovendus Amadou Samb
  • Promoters Ron Mathot Anton van Kaam
  • Co-Promoters Yuma Bijleveldt Timo de Haan
  • Jaar 2020 - 2024

Assessment of saliva/plasma ratio for drugs administered to (premature) neonates.

Farmacokinetiek en -dynamiek

Pharmacokinetics and pharmacodynamics of von Willebrand factor in patients with von Willebrand disease

  • Universiteit Amsterdam Universitair Medisch Centrum
  • Promovendus Michael Cloesmeijer
  • Promoters Ron Mathot Frank Leebeek
  • Co-Promoters Marjon Cnossen
  • Jaar 2020 - 2024

Therapeutic drug monitoring of clotting factor concentrates in patients Willebrand disease undergoing surgery.

Farmacokinetiek en -dynamiek

Pharmacokinetics and pharmacodynamics of clotting factor concentrates in hemophilia and von Willebrand disease by neural network analysis

  • Universiteit Amsterdam Universitair Medisch Centrum
  • Promovendus Alexander Janssen
  • Promoters Ron Mathot Frank Leebeek
  • Co-Promoters Marjon Cnossen
  • Jaar 2020 - 2024

Development of a webportal for TDM requests. Aplication of neural networks (deep learning) for population analysis. 

Farmacokinetiek en -dynamiek

Dose individualization of Beta-lactam and Ciprofloxacin in ICU patients: To TDM or not to TDM

  • Universiteit Erasmus Medisch Centrum Rotterdam
  • Promovendus Alan Abdulla
  • Promoters Birgit Koch
  • Co-Promoters Rik Endeman Anouk Muller
  • Jaar 2018 - 2022
  • A prospective observational PK/PD to study the target attainment for β-lactam antibiotics in critical ill patients and its associated risk factors.
  • A multi-centre, randomised controlled trial to assess the efficacy and cost-effectiveness of model-based TDM of beta-lactam and fluoroquinolone antibiotics.
Farmacokinetiek en -dynamiek

PK/PD of betalactamantibiotics

  • Universiteit Erasmus Medisch Centrum Rotterdam
  • Promovendus Eveline Roelofsen
  • Promoters Birgit Koch
  • Co-Promoters Brenda de Winter Anouk Muller
  • Jaar 2019 - 2023
  1. Optimasation of the flucloxacillin absorptiontest.
  2. PK modeeling of cefotaxim in critically ill patients.
  3. PK modeling of flucloxacillin in mice.
Farmacokinetiek en -dynamiek

Optimalisatie van tacrolimus effectiviteit in long- en nier transplantatie patienten

  • Universiteit Rijksuniversiteit Groningen
  • Promovendus Tanja Zijp
  • Promoters Prof. dr. D.J. Touw
  • Co-Promoters Job van Boven Tji Gan
  • Jaar 2019 - 2023

Ontwikkeling therapietrouw en PK gedreven interventies bij patienten met long of niertransplantatie.

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