Promotie onderzoek

Onderzoek gericht op effectieve interventies in detectie en reductie van drug-related problems (DRPs) bij kwetsbare ouderen in tweedelijnszorg. Centraal staat de vraag hoe implementatie van screening tools kan bijdragen aan effectieve zorg op de juiste plaats (targeted pharmaceutical care). Onderdeel hiervan is de ontwikkeling en effectiviteitsevaluatie van een clinical decision support tool in de optimalisatie van farmacotherapie bij ouderen.

Assessment of saliva/plasma ratio for drugs administered to (premature) neonates.

Therapeutic drug monitoring of clotting factor concentrates in patients Willebrand disease undergoing surgery.

Development of a webportal for TDM requests. Aplication of neural networks (deep learning) for population analysis. 

• A prospective observational PK/PD to study the target attainment for β-lactam antibiotics in critical ill patients and its associated risk factors.
• A multi-centre, randomised controlled trial to assess the efficacy and cost-effectiveness of model-based TDM of beta-lactam and fluoroquinolone antibiotics.

1. Optimasation of the flucloxacillin absorptiontest.
2. PK modeeling of cefotaxim in critically ill patients.
3. PK modeling of flucloxacillin in mice.

Part 1: Optimizing ribavirin therapy in transplant recipients with a chronic hepatitis E virus infection by devoloping a NONMEM model for ribavirin. Part 2: Improving immunosuppressive therapy in liver transplant recipients by performing 2 RCT's in which different immunosuppresive strategies will be compared to modify the tacrolimus related toxicity in this population. Part 3: Evaluate the contribution of an outpatient medication service for liver transplant recipients.