Use population PK/PD modeling approach and consider evolving resistance development to better understand the development of drug resistance in anti-cancer treatments and to optimize and individualize anti-cancer treatment.
Drug repositioning is the application of existing drugs to new indications. We want to find out if it is possible to find new potentially effective drugs against individual tumors based on their unique gene expression patterns.
Treosulfan is increasingly used in pediatric allogeneic HSCT. Pharmacokinetic data in children is sparse. Also the relationship with acute and late toxicity and clinical outcome is not clear yet. Our aim is to establish a popPK model, investiate the relationship between treosulfan exposure and outcome and to acquire knowledge about the acute and late side effects.
The aim of this PhD is to study the role of drug metabolism in adverse drug reactions (ADRs), an area which is not often taken into account in pharmacovigilance. The role of metabolites in ADRs is studied by focusing on (but not limiting to) a number of therapeutic drug groups.
Onderzoek naar verbeteren van communicatie bij wisselen van medicatie en in andere uitdagende situaties (laaggeletterdheid, emoties).
Onderzoeks naar verbeteren inhaltietechniek in de apotheek gesprek via een innovatieve trainingsmethode.