Het doel is het effect van farmacokinetische boosting op de farmacokinetiek, effectiviteit en toxiciteit van behandeling met olaparib te onderzoeken.
A prospective observational PK/PD to study the target attainment for β-lactam antibiotics in critically ill pediatric patients and associated risk factors.
Effect van medicatiereviews en ontslagbegeleiding door multidisciplinair team op heropnames bij hoog-risico ouderen.
Hospital expenditure of expensive drugs increases yearly. In addition, shortages are becoming more common. To assure access to healthcare and treatment in the future, sustainable use of expensive drugs is very important. This research aims to optimize treatment with regard to efficacy and safety, while aiming to reduce drug costs.