Promotie onderzoek

Het onderzoeken van PK/PD relaties middels farmacometrische modellen en de implicaties daarvan op de dagelijkse klinische praktijk op de afdeling oncologie.

The aim of the thesis is to identify and examine strategies regarding the preparation and administration of medication to improve medication safety in hospitals. Examined interventions:

1. central automated dose dispensing combined with barcode-assisted medication administration,
2. a pharmacy-based centralised intravenous admixture service.

Outpatient Parenteral Antimicrobial Therapy (OPAT) service provides antimicrobial therapy by parenteral infusion without hospitalization. Vancomycin is a widely used antibiotic in OPAT, however a drawback of its application in OPAT is the need for traditional blood sampling at a blood sampling facility for therapeutic drug monitoring. By developing a dried blood spot sampling method (i.e. a finger prick), enabling patients to collect their own sample at home, the costs of OPAT may be further reduced and patient satisfaction may be increased. 

1. Cost benefit analysis clinical medication reviews
2. Follow up of intervetnions from clinical pharmacists.
3. Medication information needs of hospitalized patients.

 A prospective observational PK/PD to study the target attainment for β-lactam antibiotics in critically ill pediatric patients and associated risk factors.