Untargeted analyses
- Universiteit Rijksuniversiteit Groningen
- Promovendus Marike Hof
- Promoters Peter Horvatovich, Daan Touw
- Co-Promoters Frank Klont
- Jaar 2022-2026
Bestudering van de post-mortale verdeling van geneesmiddelen.
All people living with HIV need life-long treatment with antiretroviral therapy (ART). However, ART coverage in children living with HIV continues to lag behind adults and many paediatric patients in sub-Saharan Africa still do not receive optimal paediatric treatment formulations or state-of-the-art drugs. Studies of efficacy and safety of these drugs in children have lagged behind, and the full range of appropriate formulations to treat younger children are yet to be developed for both first- and second-line treatments.
We aim to develop models for sepsis detection and therapeutic treatment personalization, using mechanistic modelling and ML/AI approaches.
The aim is to improve the therapeutic drug monitoring process using drug dosing software and new laboratory techniques.
Evaluation of hybrid care paths with Home Blood Pressure Telemonitoring through a quintiple aim perspective (clinical efficiency, cost-effectiveness, healthcare provider experience, patient experience and health equity).
My research focuses on therapeutic drug monitoring of antipsychotics in children with an autism spectrum disorder, and adolescents with anorexia nervosa.