Ontwikkelen van analytische tools om therapietrouw te monitoren.
Use population PK/PD modeling approach and consider evolving resistance development to better understand the development of drug resistance in anti-cancer treatments and to optimize and individualize anti-cancer treatment.
Treosulfan is increasingly used in pediatric allogeneic HSCT. Pharmacokinetic data in children is sparse. Also the relationship with acute and late toxicity and clinical outcome is not clear yet. Our aim is to establish a popPK model, investiate the relationship between treosulfan exposure and outcome and to acquire knowledge about the acute and late side effects.
Bestudering van de post-mortale verdeling van geneesmiddelen.
Onderzoek naar de interactie tussen voriconazol en verschillende toedieningsvormen van tacrolimus.
Onderzoek naar de farmacokinetiek en farmacodynamiek van fluconazol en micafungin.
Onderzoek naar de optimalisatie van clozapine therapie en effect van genetische factoren op het effect en de bijwerkingen van antisychotica en antidepressiva.