Towards precision dosing in psychiatric patients.
- Universiteit Erasmus Medisch Centrum Rotterdam
- Promovendus Kajie Liang
- Promoters prof. dr. Birgit Koch
- Co-Promoters ds dr. Bram Dierckx
- Jaar 2022- 2026
Outpatient Parenteral Antimicrobial Therapy (OPAT) service provides antimicrobial therapy by parenteral infusion without hospitalization. Vancomycin is a widely used antibiotic in OPAT, however a drawback of its application in OPAT is the need for traditional blood sampling at a blood sampling facility for therapeutic drug monitoring. By developing a dried blood spot sampling method (i.e. a finger prick), enabling patients to collect their own sample at home, the costs of OPAT may be further reduced and patient satisfaction may be increased.
A prospective observational PK/PD to study the target attainment for β-lactam antibiotics in critically ill pediatric patients and associated risk factors.
Bestudering van de post-mortale verdeling van geneesmiddelen.
Onderzoek naar de interactie tussen voriconazol en verschillende toedieningsvormen van tacrolimus.
Onderzoek naar de farmacokinetiek en farmacodynamiek van fluconazol en micafungin.
Onderzoek naar de optimalisatie van clozapine therapie en effect van genetische factoren op het effect en de bijwerkingen van antisychotica en antidepressiva.