Sexual adverse drug reactions
- Universiteit Leiden Universitair Medisch Centrum
- Promovendus Rineke Gordijn
- Promoters Prof Dr Henk-Jan Guchelaar
- Co-Promoters ds Dr Martina Teichert
- Jaar 2020-2022
Use population PK/PD modeling approach and consider evolving resistance development to better understand the development of drug resistance in anti-cancer treatments and to optimize and individualize anti-cancer treatment.
Treosulfan is increasingly used in pediatric allogeneic HSCT. Pharmacokinetic data in children is sparse. Also the relationship with acute and late toxicity and clinical outcome is not clear yet. Our aim is to establish a popPK model, investiate the relationship between treosulfan exposure and outcome and to acquire knowledge about the acute and late side effects.
Het onderzoeken van PK/PD relaties middels farmacometrische modellen en de implicaties daarvan op de dagelijkse klinische praktijk op de afdeling oncologie.
The aim of the thesis is to identify and examine strategies regarding the preparation and administration of medication to improve medication safety in hospitals. Examined interventions: