Wat is het effect van CYP2A1 remming op de bijwerkingen van clozapine.
Bestudering van de post-mortale verdeling van geneesmiddelen.
Bestudering van de post-mortale verdeling van geneesmiddelen.
All people living with HIV need life-long treatment with antiretroviral therapy (ART). However, ART coverage in children living with HIV continues to lag behind adults and many paediatric patients in sub-Saharan Africa still do not receive optimal paediatric treatment formulations or state-of-the-art drugs. Studies of efficacy and safety of these drugs in children have lagged behind, and the full range of appropriate formulations to treat younger children are yet to be developed for both first- and second-line treatments.
We aim to develop models for sepsis detection and therapeutic treatment personalization, using mechanistic modelling and ML/AI approaches.
The aim is to improve the therapeutic drug monitoring process using drug dosing software and new laboratory techniques.