Sexual adverse drug reactions
- Universiteit Leiden Universitair Medisch Centrum
- Promovendus Rineke Gordijn
- Promoters Prof Dr Henk-Jan Guchelaar
- Co-Promoters ds Dr Martina Teichert
- Jaar 2020-2022
Use population PK/PD modeling approach and consider evolving resistance development to better understand the development of drug resistance in anti-cancer treatments and to optimize and individualize anti-cancer treatment.
Treosulfan is increasingly used in pediatric allogeneic HSCT. Pharmacokinetic data in children is sparse. Also the relationship with acute and late toxicity and clinical outcome is not clear yet. Our aim is to establish a popPK model, investiate the relationship between treosulfan exposure and outcome and to acquire knowledge about the acute and late side effects.
The aim of this PhD is to study the role of drug metabolism in adverse drug reactions (ADRs), an area which is not often taken into account in pharmacovigilance. The role of metabolites in ADRs is studied by focusing on (but not limiting to) a number of therapeutic drug groups.
Onderzoeksprojekt over de mogelijkheden die de beweging naar continue
farmaceutische patiëntenzorg helpen mogelijk te maken dan wel te versnellen.
European funded project to reduce the inappropriate use of antibiotics in common infectious diseases by implementing EU guidelines for the prudent use of antimicrobials in human health. Implementing the Audit Project Odense (APO) methodology in community pharmacies in 5 European countries (France, Spain, Lithuania, Poland and Greece).
Drug utilization of antihypertensives in the Baltic countries.