Treosulfan pharmacokinetics and dynamics in pediatric allogeneic stem cell transplantation
- Universiteit Leiden Universitair Medisch Centrum
- Promovendus Eileen van der Stoep
- Promoters Prof Dr Arjan Lankester Prof Dr Henk-Jan Guchelaar
- Co-Promoters ds Dr J Zwaveling
- Jaar 2015-2022
Treosulfan is increasingly used in pediatric allogeneic HSCT. Pharmacokinetic data in children is sparse. Also the relationship with acute and late toxicity and clinical outcome is not clear yet. Our aim is to establish a popPK model, investiate the relationship between treosulfan exposure and outcome and to acquire knowledge about the acute and late side effects.