Farmacokinetiek en -dynamiek
Bioanalysis and Biotransformation of Covalent Targeted Kinase Inhibitors in Oncology
- Universiteit Universiteit Utrecht
- Promovendus Irene Retmana
- Promoters Beijnen
- Co-Promoters ds Sparidans
- Jaar 2020 - 2024
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Er zijn11resultaten gevonden
Farmacogenetica
Pharmacogenetics of platinumbased chemotherapy in non-small cell lung cancer
- Universiteit Universiteit Utrecht
- Promovendus Corine de Jong
- Promoters Toine Egberts
- Co-Promoters ds Judith Herder Vera Deneer
- Jaar 2018 - 2022
Identificeren van biomarkers, waaronder genetische variaties, die geassocieerd zijn met de effectiviteit en toxiciteit van platinumhoudende chemotherapie in de behandeling van patiënten met niet-kleincellig longcarcinoom.
Farmacokinetiek en -dynamiek
Biobased factor VIII therapies in hemophilia A patients
- Universiteit Universiteit Utrecht
- Promovendus Anouk Donners
- Promoters Toine Egberts
- Co-Promoters ds Karin Rademaker Erik van Maarseveen
- Jaar 2018 - 2022
The landscape of drug development as well as clinical practice has been changing over the last decennium, with the increasing availability and use of biobased therapies. This research is now focusing on the use and therapeutic drug monitoring of biobased factor VIII therapies in hemophilia A patients.
Farmacokinetiek en -dynamiek
Dose individualization of Beta-lactam and Ciprofloxacin in ICU patients: To TDM or not to TDM
- Universiteit Erasmus Medisch Centrum Rotterdam
- Promovendus Alan Abdulla
- Promoters Birgit Koch
- Co-Promoters ds Rik Endeman Anouk Muller
- Jaar 2018 - 2022
- A prospective observational PK/PD to study the target attainment for β-lactam antibiotics in critical ill patients and its associated risk factors.
- A multi-centre, randomised controlled trial to assess the efficacy and cost-effectiveness of model-based TDM of beta-lactam and fluoroquinolone antibiotics.
Farmacokinetiek en -dynamiek
PK/PD of betalactamantibiotics
- Universiteit Erasmus Medisch Centrum Rotterdam
- Promovendus Eveline Roelofsen
- Promoters Birgit Koch
- Co-Promoters ds Brenda de Winter Anouk Muller
- Jaar 2019 - 2023
- Optimasation of the flucloxacillin absorptiontest.
- PK modeeling of cefotaxim in critically ill patients.
- PK modeling of flucloxacillin in mice.
Farmacokinetiek en -dynamiek
Improving the pharmaceutical care for (liver) transplant recipients
- Universiteit Erasmus Medisch Centrum Rotterdam
- Promovendus Midas B. Mulder
- Promoters Prof. Dr. Herold Metselaar
- Co-Promoters ds Dr. B.C.M. de Winter Dr. S. Darwish Murad
- Jaar 2019 - 2023
Part 1: Optimizing ribavirin therapy in transplant recipients with a chronic hepatitis E virus infection by devoloping a NONMEM model for ribavirin. Part 2: Improving immunosuppressive therapy in liver transplant recipients by performing 2 RCT's in which different immunosuppresive strategies will be compared to modify the tacrolimus related toxicity in this population. Part 3: Evaluate the contribution of an outpatient medication service for liver transplant recipients.
Farmacokinetiek en -dynamiek
The impact of continuous renal replacement therapy and hyperinflammation on the pharmacokinetics in intensive care unit patients
- Universiteit Erasmus Medisch Centrum Rotterdam
- Promovendus Tim Smeets
- Promoters prof. dr. Birgit Koch prof. dr. Diederik Gommers
- Co-Promoters ds dr. Nicole G.M. Hunfeld dr. Henrik Endeman
- Jaar 2021-2023
- To study the impact of inflammation on midazolam pharmacokinetics in critically ill covid-19 patients.
- To study the impact of continuous renal replacement therapy on target attainment and pharmacokinetics of drugs in critically ill patients.
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