Promotie onderzoek

Onderzoek in Spanje

Het onderzoek is gericht op het verbeteren van immuunsupressieve therapie bij niertransplantatiepatiënten met behulp van PK-PD modelling.

Onderzoek in India

1. To study the impact of inflammation on midazolam pharmacokinetics in critically ill covid-19 patients.
2. To study the impact of continuous renal replacement therapy on target attainment and pharmacokinetics of drugs in critically ill patients.

Use population PK/PD modeling approach and consider evolving resistance development to better understand the development of drug resistance in anti-cancer treatments and to optimize and individualize anti-cancer treatment.

Treosulfan is increasingly used in pediatric allogeneic HSCT. Pharmacokinetic data in children is sparse. Also the relationship with acute and late toxicity and clinical outcome is not clear yet. Our aim is to establish a popPK model, investiate the relationship between treosulfan exposure and outcome and to acquire knowledge about the acute and late side effects. 

Het onderzoeken van PK/PD relaties middels farmacometrische modellen en de implicaties daarvan op de dagelijkse klinische praktijk op de afdeling oncologie.