Dose individualization of Beta-lactam and Ciprofloxacin in ICU patients: To TDM or not to TDM

Farmacokinetiek en -dynamiek

  • A prospective observational PK/PD to study the target attainment for β-lactam antibiotics in critical ill patients and its associated risk factors.
  • A multi-centre, randomised controlled trial to assess the efficacy and cost-effectiveness of model-based TDM of beta-lactam and fluoroquinolone antibiotics.



Erasmus MC

Alan Abdulla

Birgit Koch

Rik Endeman
Anouk Muller