Background information pharmacogenetics

For every enzyme (gene) general background information is available. In this document you can find information about pharmacogenetics in general and information about the variants of the specific enzyme.

The general background information files are listed below:

Algorithms coumarins

Variants in CYP2C9 and VKORC1 are relevant for the loading- and maintenance dose of coumarins. In the EU-PACT study algorithms are used for acenocoumarol, phenprocoumon and warfarin (warfarin in barely used in the Netherlands). The algorithm provides a more accurate estimate of the dose than the seperate pharmacogenetic recommendations for CYP2C9 and VKORC1; the recommendations refer to these algorithms.

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