Warfarin loading doses - calculation for different genotypes

Variants in CYP2C9 and VKORC1 are relevant for the loading- and maintenance dose of coumarins. In the EU-PACT study algorithms are used for acencoumarol, phenprocoumon and warfarin (warfarin in barely used in the Netherlands). The algorithm provides a more accurate estimate of the dose than the seperate pharmacogenetic recommendations for CYP2C9 and VKORC1; the recommendations refer to these algorithms.

Office Excel 2007 XML workbook, 16 KB (16903 bytes) warfarin loading doses_calculation for different genotypes.xlsx