Warfarin doses day 4 and 5 - calculation for different genotypes

Variants in CYP2C9 and VKORC1 are relevant for the loading- and maintenance dose of coumarins. In the EU-PACT study algorithms are used for acencoumarol, phenprocoumon and warfarin (warfarin in barely used in the Netherlands). The algorithm provides a more accurate estimate of the dose than the seperate pharmacogenetic recommendations for CYP2C9 and VKORC1; the recommendations refer to these algorithms.

application/vnd.openxmlformats-officedocument.spreadsheetml.sheet, 17 KB (17650 bytes) warfarin doses day 4 and 5_calculation for different genotypes.xlsx