English background information

For every enzyme (gene) general background information is available. Here you can find documents with information about pharmacogenetics in general and information about the variants of the specific enzyme.

Acenocoumarol and phenprocoumon algorithm

Variants in CYP2C9 and VKORC1 are relevant for the loading- and maintenance dose of coumarins. In the EU-PACT study algorithms are used for acencoumarol, phenprocoumon and warfarin (warfarin in barely used in the Netherlands). The algorithm provides a more accurate estimate of the dose than the seperate pharmacogenetic recommendations for CYP2C9 and VKORC1; the recommendations refer to these algorithms.

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Warfarin doses day 4 and 5 - calculation for different genotypes

Variants in CYP2C9 and VKORC1 are relevant for the loading- and maintenance dose of coumarins. In the EU-PACT study algorithms are used for acencoumarol, phenprocoumon and warfarin (warfarin in barely used in the Netherlands). The algorithm provides a more accurate estimate of the dose than the seperate pharmacogenetic recommendations for CYP2C9 and VKORC1; the recommendations refer to these algorithms.

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Warfarin loading doses - calculation for different genotypes

Variants in CYP2C9 and VKORC1 are relevant for the loading- and maintenance dose of coumarins. In the EU-PACT study algorithms are used for acencoumarol, phenprocoumon and warfarin (warfarin in barely used in the Netherlands). The algorithm provides a more accurate estimate of the dose than the seperate pharmacogenetic recommendations for CYP2C9 and VKORC1; the recommendations refer to these algorithms.

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CYP1A2 English

General background information CYP1A2.

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CYP2B6 English

General background information CYP2B6.

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CYP2C9 English

General background information CYP2C9.

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CYP2C19 English

General background information CYP2C19.

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CYP3A5 English

General background information CYP3A5.

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HLA English

General background information HLA.

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TMPT English

General background information TPMT.

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CYP2D6 English

General background information CYP2D6.

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CYP3A4 English

General background information CYP3A4.

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DPD English

General background information DPD.

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Factor V Leiden English

General background information Factor V Leiden.

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MTHFR English

General background information MTHFR.

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SLCO1B1 English

General background information SLCO1B1.

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UGT1A1 English

General background information UGT1A1.

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VKORC1 English

General background information VKORC1.

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