English background information
For every enzyme (gene) general background information is available. Here you can find documents with information about pharmacogenetics in general and information about the variants of the specific enzyme.
Acenocoumarol and phenprocoumon algorithm
Variants in CYP2C9 and VKORC1 are relevant for the loading- and maintenance dose of coumarins. In the EU-PACT study algorithms are used for acencoumarol, phenprocoumon and warfarin (warfarin in barely used in the Netherlands). The algorithm provides a more accurate estimate of the dose than the seperate pharmacogenetic recommendations for CYP2C9 and VKORC1; the recommendations refer to these algorithms.
Lees verderWarfarin doses day 4 and 5 - calculation for different genotypes
Variants in CYP2C9 and VKORC1 are relevant for the loading- and maintenance dose of coumarins. In the EU-PACT study algorithms are used for acencoumarol, phenprocoumon and warfarin (warfarin in barely used in the Netherlands). The algorithm provides a more accurate estimate of the dose than the seperate pharmacogenetic recommendations for CYP2C9 and VKORC1; the recommendations refer to these algorithms.
Lees verderWarfarin loading doses - calculation for different genotypes
Variants in CYP2C9 and VKORC1 are relevant for the loading- and maintenance dose of coumarins. In the EU-PACT study algorithms are used for acencoumarol, phenprocoumon and warfarin (warfarin in barely used in the Netherlands). The algorithm provides a more accurate estimate of the dose than the seperate pharmacogenetic recommendations for CYP2C9 and VKORC1; the recommendations refer to these algorithms.
Lees verder