English background information
Acenocoumarol and phenprocoumon algorithm
Variants in CYP2C9 and VKORC1 are relevant for the loading- and maintenance dose of coumarins. In the EU-PACT study algorithms are used for acencoumarol, phenprocoumon and warfarin (warfarin in barely used in the Netherlands). The algorithm provides a more accurate estimate of the dose than the seperate pharmacogenetic recommendations for CYP2C9 and VKORC1; the recommendations refer to these algorithms.
Lees verderWarfarin doses day 4 and 5 - calculation for different genotypes
Variants in CYP2C9 and VKORC1 are relevant for the loading- and maintenance dose of coumarins. In the EU-PACT study algorithms are used for acencoumarol, phenprocoumon and warfarin (warfarin in barely used in the Netherlands). The algorithm provides a more accurate estimate of the dose than the seperate pharmacogenetic recommendations for CYP2C9 and VKORC1; the recommendations refer to these algorithms.
Lees verderWarfarin loading doses - calculation for different genotypes
Variants in CYP2C9 and VKORC1 are relevant for the loading- and maintenance dose of coumarins. In the EU-PACT study algorithms are used for acencoumarol, phenprocoumon and warfarin (warfarin in barely used in the Netherlands). The algorithm provides a more accurate estimate of the dose than the seperate pharmacogenetic recommendations for CYP2C9 and VKORC1; the recommendations refer to these algorithms.
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